Dnaaf1 Gene Summary [Rat]
Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including cilium assembly; determination of left/right symmetry; and regulation of cilium beat frequency. Predicted to be located in cilium. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaaf1 |
| Official Name | dynein, axonemal, assembly factor 1 [Source:RGD Symbol;Acc:1310542] |
| Ensembl ID | ENSRNOG00000015590 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, assembly factor 1 |
| Synonyms | 4930457P18Rik, CILD13, DAU1, dynein axonemal assembly factor 1, dynein, axonemal assembly factor 1, dynein, axonemal, assembly factor 1, LRRC50, m4Bei, ODA7, RGD1310542, swt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnaaf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- binding protein
- Leucine rich repeat
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- situs ambiguus
- primary ciliary dyskinesia
- primary ciliary dyskinesia type 13
regulates
- Axonemal Dynein Outer Arm
- Axonemal Dynein
- Axonemal Dynein Inner Arm
role in cell
- assembly
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- axonemes
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnaaf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cilium movement involved in determination of left/right asymmetry
- outer dynein arm assembly
- cilium morphogenesis
- determination of digestive tract left/right asymmetry
- axoneme assembly
- cilium movement
- motile cilium assembly
- left/right pattern formation
- regulation of cilium beat frequency
- axonemal dynein complex assembly
- heart looping
- inner dynein arm assembly
- determination of liver left/right asymmetry
- determination of pancreatic left/right asymmetry
- lung development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- spindle pole
- cytosol
- extracellular region
- axoneme
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- dynein complex binding