Guca1b Gene Summary [Rat]
Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction and visual perception. Predicted to act upstream of or within phototransduction and regulation of guanylate cyclase activity. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa 48. Orthologous to human GUCA1B (guanylate cyclase activator 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Guca1b |
| Official Name | guanylate cyclase activator 1B [Source:RGD Symbol;Acc:1308191] |
| Ensembl ID | ENSRNOG00000015623 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 1B |
| Synonyms | AC112683.3, GCAP-2, GCAP-II, guanylate cyclase activator 1B, GUCA2, RP48 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Guca1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- EF-hand, calcium binding motif
- EF-hand domain
- calcium sensitive guanylate cyclase activator
- EF-hand domain pair
- EF hand
- EFh
- protein binding
- guanylate cyclase regulator
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the Guca1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- cellular membrane
- basal bodies
- nucleoplasm
- nuclear envelope
- photoreceptor outer segments
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Guca1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of guanylate cyclase activity
- cell-cell signaling
- receptor guanylyl cyclase signaling pathway
- visual perception
- body fluid secretion
Cellular Component
Where in the cell the gene product is active
- photoreceptor inner segment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- calcium sensitive guanylate cyclase activator activity