C1rl Gene Summary [Rat]

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in blood microparticle. Orthologous to human C1RL (complement C1r subcomponent like). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
C1rl
Official Name
complement C1r subcomponent like [Source:RGD Symbol;Acc:1302936]
Ensembl ID
ENSRNOG00000011718
Bio databases IDs NCBI: 408246 Ensembl: ENSRNOG00000011718
Aliases complement C1r subcomponent like
Synonyms C1RL1, C1RLP, CLSPa, complement C1r subcomponent like, complement component 1, r subcomponent-like
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1rl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Trypsin-like serine protease
  • trypsin
  • Tryp_SPc
  • CUB
  • peptidase
  • active site

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • liver cancer
  • diabetic nephropathy
  • COVID-19
  • hepatitis B virus-related hepatocellular carcinoma
regulated by
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat C1rl gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • zymogen activation
  • innate immune response
  • complement activation, classical pathway

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular vesicular exosome

Molecular Function

What the gene product does at the molecular level
  • serine-type endopeptidase activity