Pex3 Gene Summary [Rat]
Predicted to enable lipid binding activity and protein-macromolecule adaptor activity. Involved in peroxisome membrane biogenesis. Located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 10B and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex3 |
| Official Name | peroxisomal biogenesis factor 3 [Source:RGD Symbol;Acc:621636] |
| Ensembl ID | ENSRNOG00000015660 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 3 |
| Synonyms | 1700014F15Rik, 2810027F19Rik, 2900010N04Rik, LOC153914, PBD10A, PBD10B, peroxisomal biogenesis factor 3, PEX3P, TRG18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- Peroxin-3
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- peroxisome biogenesis disorder 10b
- peroxisome biogenesis disorder 10a (Zellweger)
- multiple sclerosis
- Graves ophthalmopathy
- hearing loss
- infantile refsum disease
- chronic obstructive pulmonary disease
- peroxisome biogenesis disorder
- Zellweger peroxisome biogenesis disorder 1A
regulates
- PMP
- 30:0-o phosphatidylethanolamine plasmalogen
- choline plasmalogens
- 34-0-p-phosphatidylcholine plasmalogen
- MARCHF5
- 32:0p phosphatidylcholine-plasmalogen
- 32:0-o phosphatidylethanolamine plasmalogen
- 38:0-o phosphatidylethanolamine plasmalogen
- plasmenyl-phosphatidylethanolamine
- 40:0-o phosphatidylethanolamine plasmalogen
role in cell
- apoptosis
- organization
- disruption
- restoration
- assembly
- vemurafenib sensitivity
- cobimetinib sensitivity
- biogenesis
- synthesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- peroxisome membrane
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome membrane
- peroxisome organization
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- membrane
- protein-lipid complex
- endoplasmic reticulum
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding
- protein binding, bridging