Cers2 Gene Summary [Rat]
Predicted to enable sphingosine N-acyltransferase activity. Involved in several processes, including negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum. Biomarker of sciatic neuropathy. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cers2 |
| Official Name | ceramide synthase 2 [Source:RGD Symbol;Acc:1310059] |
| Ensembl ID | ENSRNOG00000021138 |
| Bio databases IDs | |
| Aliases | ceramide synthase 2 |
| Synonyms | 0610013I17RIK, ceramide synthase 2, L3, LASS2, SP260, TMSG1, TRH3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cers2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- transcription regulator
- sphingosine N-acyltransferase
- N-acyltransferase
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- prostate cancer
- impaired glucose tolerance
- metastasis
- astrocytosis
- prostatic carcinoma
- cutaneous melanoma
- cutaneous melanoma cancer
role in cell
- proliferation
- migration
- cell death
- expression in
- phosphorylation in
- apoptosis
- synthesis in
- quantity
- degeneration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fimbria
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cers2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of axon regeneration
- ceramide biosynthetic process
- negative regulation of Schwann cell migration
- response to immobilization stress
- regulation of lipid metabolic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sphingosine N-acyltransferase activity