Abcd1 Gene Summary [Rat]
Enables ATP binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcd1 |
| Official Name | ATP binding cassette subfamily D member 1 [Source:RGD Symbol;Acc:1562128] |
| Ensembl ID | ENSRNOG00000056524 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily D member 1 |
| Synonyms | ABC42, ALD, Aldgh, ALDP, AMN, ATP binding cassette subfamily D member 1, ATP-binding cassette, sub-family D member 1, ATP-binding cassette, subfamily D, member 1, RGD1562128 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FeS assembly ATPase SufC
- Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
- walker type B motif
- ADP binding
- ATP binding
- identical protein binding
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- organophosphate ester transporter
- nickel import ATP-binding protein NikE
- nucleotide binding fold domain
- acyl-CoA hydrolase
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- amide transporter
- walker type A motif
- enzyme binding
- protein binding
- ABC transporter transmembrane region 2
- long-chain fatty acid transporter
- cobalt transport protein ATP-binding subunit
- fatty acyl CoA transporter
- nucleobase, nucleoside, nucleotide and nucleic acid transporter
- transmembrane domain
- protein homodimerization
- ABC transporter
- protein heterodimerization
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked adrenoleukodystrophy
- adrenoleukodystrophy
- adrenomyeloneuropathy
- hereditary disorder
- astrocytosis
- familial Addison disease
- spondyloepimetaphyseal dysplasia, x-linked type
- mental retardation
- Addison disease
- childhood cerebral adrenoleukodystrophy
role in cell
- expression in
- binding in
- accumulation in
- survival
- depolarization
- interaction
- quantity
- production in
- biogenesis
- biogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- mitochondrial membrane
- lysosome membrane
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very long-chain fatty-acyl-CoA catabolic process
- long-chain fatty acid catabolic process
- positive regulation of fatty acid beta-oxidation
- positive regulation of unsaturated fatty acid biosynthetic process
- regulation of oxidative phosphorylation
- fatty acid homeostasis
- peroxisome organization
- linoleic acid metabolic process
- very long-chain fatty acid catabolic process
- negative regulation of cytokine production involved in inflammatory response
- very long-chain fatty acid metabolic process
- myelin maintenance
- sterol homeostasis
- regulation of cellular response to oxidative stress
- fatty acid beta-oxidation
- regulation of fatty acid beta-oxidation
- peroxisomal membrane transport
- fatty-acyl-CoA transport
- alpha-linolenic acid metabolic process
- fatty acid elongation
- regulation of mitochondrial depolarization
- peroxisomal long-chain fatty acid import
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- peroxisome
- perinuclear region of cytoplasm
- mitochondrial membrane
- cytoplasm
- membrane
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATPase activity, coupled to transmembrane movement of substances
- identical protein binding
- protein homodimerization activity
- ADP binding
- acyl-CoA hydrolase activity
- long-chain fatty acid transporter activity
- ATP binding
- protein binding
- protein heterodimerization activity
- fatty-acyl-CoA transporter activity
- very long chain acyl-CoA hydrolase activity
- enzyme binding