Ndst3 Gene Summary [Rat]
Predicted to enable N-acetylglucosamine deacetylase activity; heparan sulfate N-deacetylase activity; and heparan sulfate N-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndst3 |
| Official Name | N-deacetylase and N-sulfotransferase 3 [Source:RGD Symbol;Acc:1310960] |
| Ensembl ID | ENSRNOG00000015781 |
| Bio databases IDs | |
| Aliases | N-deacetylase and N-sulfotransferase 3 |
| Synonyms | HSST3, N-deacetylase and N-sulfotransferase 3, N-deacetylase and N-sulphotransferase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndst3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- N-acetylglucosamine deacetylase
- Sulfotransferase domain
- enzyme
- deacetylase
- Sulfotransferase family
- heparan sulfate-N-deacetylase
Pathways
Biological processes and signaling networks where the Ndst3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- frontotemporal dementia and/or amyotrophic lateral sclerosis type 1
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- restless legs syndrome
regulated by
- ZBTB16
- C9orf72
regulates
- heparan sulfate proteoglycan
- alpha tubulin
role in cell
- acidification in
- acidification
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndst3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- heparin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine N-sulfotransferase activity
- deacetylase activity