LOC108349548 Gene Summary [Rat]
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | LOC108349548 |
| Official Name | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [Source:RGD Symbol;Acc:11485321] |
| Ensembl ID | ENSRNOG00000015936 |
| Bio databases IDs | |
| Aliases | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 |
| Synonyms | GNGT5, G protein subunit gamma 5, G protein subunit γ 5, G protein γ 5, G(y)5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108349548 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGL
- protein binding
- GGL domain
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Loc108349548 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108349548 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- positive regulation of neural precursor cell proliferation
- positive regulation of secondary heart field cardioblast proliferation
Cellular Component
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding
- GTPase activity
- PDZ domain binding