Zc3h12d Gene Summary [Rat]
Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of cell growth. Predicted to act upstream of or within mRNA catabolic process and negative regulation of T cell proliferation. Predicted to be located in P-body and nucleoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12D (zinc finger CCCH-type containing 12D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zc3h12d |
| Official Name | zinc finger CCCH type containing 12D [Source:RGD Symbol;Acc:1597152] |
| Ensembl ID | ENSRNOG00000016041 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH type containing 12D |
| Synonyms | C6orf95, D730019B10Rik, dJ281H8.1, MCPIP4, p34, TFL, zinc finger CCCH-type containing 12D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zc3h12d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA-binding, Nab2-type zinc finger
- UBA-like domain
- protein binding
- Zc3h12a-like Ribonuclease NYN domain
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- coronary artery disease
- asthma
- Dupuytren contracture
role in cell
- proliferation
- expression in
- phosphorylation in
- growth
- number
- G1/S phase transition
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Nucleus
- granules
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zc3h12d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- mRNA binding
- endoribonuclease activity