Zap70 Gene Summary [Rat]
Predicted to enable ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in immune response. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in several cellular components, including cell-cell junction; immunological synapse; and membrane raft. Predicted to be part of T cell receptor complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zap70 |
| Official Name | zeta chain of T cell receptor associated protein kinase 70 [Source:RGD Symbol;Acc:3983] |
| Ensembl ID | ENSRNOG00000016995 |
| Bio databases IDs | |
| Aliases | zeta chain of T cell receptor associated protein kinase 70 |
| Synonyms | ADMIO2, IMD48, mrtle, mur, SRK, STCD, STD, TZK, zeta chain of T cell receptor associated protein kinase 70, zeta-chain (TCR) associated protein kinase, ζ chain of T cell receptor associated protein kinase 70, ζ-chain (TCR) associated protein kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zap70 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- central domain
- non-membrane spanning protein tyrosine kinase
- linker domain
- phosphotyrosine binding
- protein binding
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- activation loop
- kinase
- Serine/Threonine protein kinases, catalytic domain
- TKB domain binding domain
- kinase domain
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Zap70 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Calcium-induced T Lymphocyte Apoptosis
- CD28 Signaling in T Helper Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- iCOS-iCOSL Signaling in T Helper Cells
- IL-15 Production
- Natural Killer Cell Signaling
- NF-κB Signaling
- PKCθ Signaling in T Lymphocytes
- Primary Immunodeficiency Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Sperm Motility
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- acute myeloid leukemia
- septic shock
- Waldenström macroglobulinemia
- selective T-cell defect
- endometrial cancer
- metastasis
- posterior cortical atrophy
- androgenic alopecia
- infantile-onset multisystem autoimmune disease type 2
role in cell
- phosphorylation in
- proliferation
- expression in
- signaling in
- activation in
- cell death
- number
- apoptosis
- activation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- raft fractions
- soluble fraction
- membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- cellular membrane
- cell cortex
- Nucleus
- intercellular junctions
- immunological synapses
- cytosol
- membrane rafts
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zap70 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- T cell activation
- transmembrane receptor protein tyrosine kinase signaling pathway
- adaptive immune response
- B cell activation
- positive thymic T cell selection
- beta selection
- protein phosphorylation
- positive regulation of alpha-beta T cell differentiation
- T cell differentiation
- positive regulation of calcium-mediated signaling
- immune response
- positive regulation of alpha-beta T cell proliferation
- positive regulation of T cell differentiation
- innate immune response
- T cell aggregation
- cell differentiation
- T cell migration
- calcium-mediated signaling
- negative thymic T cell selection
- intracellular signal transduction
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- membrane raft
- cytosol
- extrinsic to internal side of plasma membrane
- T cell receptor complex
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding