Adam2 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Involved in male gonad development and spermatogenesis. Located in acrosomal vesicle. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam2 |
| Official Name | ADAM metallopeptidase domain 2 [Source:RGD Symbol;Acc:69299] |
| Ensembl ID | ENSRNOG00000017027 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 2 |
| Synonyms | ADAM metallopeptidase domain 2, a disintegrin and metallopeptidase domain 2, CRYN1, CRYN2, CT15, fertilin beta, Fertilin β, FTNB, PH-30, PH-30b, PH30-beta, PH30-β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- metallopeptidase
- ZnMc
- ADAM cysteine-rich
- peptidase
- integrin binding
- active site
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
- disintergrin domain
Pathways
Biological processes and signaling networks where the Adam2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- cell surface
- cellular membrane
- acrosome
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- male gonad development
- positive regulation of gene expression
- proteolysis
- cell adhesion
- fusion of sperm to egg plasma membrane
- visual learning
- adult behavior
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- integrin binding
- metalloendopeptidase activity
- metallopeptidase activity