Itga4 Gene Summary [Rat]
Enables cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and regulation of leukocyte migration. Located in cell surface; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga4 |
| Official Name | integrin subunit alpha 4 [Source:RGD Symbol;Acc:1593249] |
| Ensembl ID | ENSRNOG00000004861 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 4 |
| Synonyms | Alpha4 Integrin, CD49D, IA4, integrin alpha 4, integrin subunit alpha 4, integrin subunit α 4, Integrin-α 4, Very late antigen-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cell adhesion molecule binding
- paxillin-binding domain
- antigen binding
- protein binding
- fibronectin binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- C-X3-C chemokine binding
- integrin binding
- tail domain
- cytosolic tail domain
- FG-GAP repeat
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Itga4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Agrin Interactions at Neuromuscular Junction
- Atherosclerosis Signaling
- Caveolar-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Granulocyte Adhesion and Diapedesis
- HGF Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- diarrhea
- septic shock
- bleeding
- sepsis
- Crohn disease
- neoplasia
- experimental autoimmune encephalomyelitis
- metastasis
- cancer
role in cell
- expression in
- number
- production in
- adhesion
- trafficking
- formation
- proliferation
- phosphorylation in
- activation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- cell surface
- cell borders
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- membrane ruffles
- plasma membrane extracellular face
- cell membrane-lagging edges
- growth cone
- membrane processes
- cell membrane leading edge
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itga4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- axonogenesis involved in innervation
- B cell differentiation
- negative regulation of vasoconstriction
- diapedesis
- negative regulation of protein homodimerization activity
- receptor clustering
- immune response in gut-associated lymphoid tissue
- cell-matrix adhesion involved in ameboidal cell migration
- leukocyte cell-cell adhesion
- positive regulation of T cell migration
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- endodermal cell differentiation
- cell-cell adhesion mediated by integrin
- cellular response to cytokine stimulus
- positive regulation of endothelial cell apoptotic process
- leukocyte tethering or rolling
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular vesicular exosome
- focal adhesion
- membrane
- external side of plasma membrane
- neuronal cell body
- alpha4-beta7 integrin complex
- integrin complex
- alpha4-beta1 integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- metal ion binding
- cell adhesion molecule binding
- fibronectin binding
- C-X3-C chemokine binding
- integrin binding