Babam1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within hematopoietic stem cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Babam1 |
| Official Name | BRISC and BRCA1 A complex member 1 [Source:RGD Symbol;Acc:1359516] |
| Ensembl ID | ENSRNOG00000017071 |
| Bio databases IDs | |
| Aliases | BRISC and BRCA1 A complex member 1 |
| Synonyms | 5430437P03Rik, BRISC and BRCA1 A complex member 1, C19orf62, FLJ20571, HSPC142, MERIT40, NBA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Babam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vWFA
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Babam1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- epithelial ovarian cancer
- ovarian carcinoma
- organismal death
- estrogen receptor-negative breast cancer
- chromosomal instability
- COVID-19
- abdominal aortic aneurysm
regulated by
- lipopolysaccharide
- ABL2
- ABL1/2
- D-galactosamine
- WWOX
- ficusin
regulates
role in cell
- proliferation
- G2/M phase
- K63 polyubiquitination in
- initial DNA end resection
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Babam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- regulation of DNA repair
- hemopoietic stem cell proliferation
- response to ionizing radiation
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- BRISC complex
- cytoplasm
- cytosol
- BRCA1-A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding