BABAM1 Gene Summary [Human]
Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and protein K63-linked deubiquitination. Located in cytosol and nuclear body. Part of BRCA1-A complex and BRISC complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BABAM1 |
| Official Name | BRISC and BRCA1 A complex member 1 [Source:HGNC Symbol;Acc:HGNC:25008] |
| Ensembl ID | ENSG00000105393 |
| Bio databases IDs | |
| Aliases | BRISC and BRCA1 A complex member 1, Mediator of Rap80 Interactions and Targeting 40 kD, new component of the BRCA1 A complex |
| Synonyms | 5430437P03Rik, BRISC and BRCA1 A complex member 1, C19orf62, FLJ20571, HSPC142, MERIT40, NBA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BABAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vWFA
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the BABAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- epithelial ovarian cancer
- ovarian carcinoma
- organismal death
- estrogen receptor-negative breast cancer
- chromosomal instability
- COVID-19
- abdominal aortic aneurysm
regulates
role in cell
- proliferation
- G2/M phase
- K63 polyubiquitination in
- initial DNA end resection
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BABAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- regulation of DNA repair
- hemopoietic stem cell proliferation
- response to ionizing radiation
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- BRISC complex
- cytoplasm
- cytosol
- BRCA1-A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding