Akt1 Gene Summary [Rat]
Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular hyperosmotic salinity response; protein phosphorylation; and regulation of protein metabolic process. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of sodium ion transport; and regulation of protein localization. Located in cytosol; dendrite; and nucleus. Used to study artery disease (multiple); autosomal recessive polycystic kidney disease; heroin dependence; impotence; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; liver disease (multiple); opiate dependence; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akt1 |
| Official Name | AKT serine/threonine kinase 1 [Source:RGD Symbol;Acc:2081] |
| Ensembl ID | ENSRNOG00000028629 |
| Bio databases IDs | |
| Aliases | AKT serine/threonine kinase 1 |
| Synonyms | AKT, AKT serine/threonine kinase 1, LTR-akt, PKB, PKB/Akt, PKB-ALPHA, PKB-α, PRKBA, Protein kinase B, RAC, RAC-ALPHA, RAC-α, Thymoma proto-oncogene 1, thymoma viral proto-oncogene 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- PDK1 regulatory site
- membrane-association domain
- S-nitrosylation site
- identical protein binding
- activation loop
- nitric oxide synthase regulator
- serine phosphorylation site
- tail domain
- activation domain
- protein kinase binding
- calmodulin binding
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- protein kinase C binding
- potassium channel regulator
- linker domain
- protein binding
- threonine phosphorylation site
- acidic domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- threonine in the turn motif
- protein homodimerization
- myristoylation signal domain
- protein kinase
- regulatory domain
- ATP-binding domain
- phosphoinositide binding domain
- ATP binding
- Protein kinase domain
- proline rich domain
- Extension to Ser/Thr-type protein kinases
- phosphatidylinositol-3,4,5-triphosphate binding
- PH domain
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- channel regulator
- autoinhibitory protein domain
- enzyme binding
- Pleckstrin homology-like domain
- phosphorylation site
- protein serine/threonine kinase inhibitor
- binding protein
- kinase binding
- Protein Kinases, catalytic domain
- PXXP motif
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Akt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CNTF Signaling
- CXCR4 Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Hypoxia Signaling in the Cardiovascular System
- IGF-1 Signaling
- IL-22 Signaling
- JAK/Stat Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neurotrophin/TRK Signaling
- Prostate Cancer Signaling
- PXR/RXR Activation
- RANK Signaling in Osteoclasts
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cancer
- non-small cell lung cancer
- ovarian cancer
- colon cancer
- breast cancer
- squamous cell lung cancer
- endometrial carcinoma
- head and neck squamous cell carcinoma
- Merkel-cell carcinoma
- uterine cancer
role in cell
- apoptosis
- necroptosis
- cell death
- production in
- activation in
- expression in
- autophagy by
- growth
- necrosis
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- high-density microsomal fractions
- raft fractions
- low-density microsomal fraction
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- spindle apparatus
- cilia
- cell periphery
- cellular membrane
- Nucleus
- Plasma Membrane
- basal bodies
- vesicles
- Mitochondria
- intercellular junctions
- cytosol
- membrane ruffles
- mitochondrial intermembrane space
- nucleoplasm
- spine apparatus
- neurites
- intercalated disks
- smooth endoplasmatic reticulum
- membrane rafts
- brush border
- cell membrane leading edge
- perikaryon
- dendrites
- axon terminals
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to growth factor stimulus
- positive regulation of sequence-specific DNA binding transcription factor activity
- cellular response to prostaglandin E stimulus
- mammary gland epithelial cell differentiation
- positive regulation of protein metabolic process
- positive regulation of cell growth
- inflammatory response
- negative regulation of fatty acid beta-oxidation
- positive regulation of nitric-oxide synthase activity
- positive regulation of transcription, DNA-dependent
- peripheral nervous system myelin maintenance
- intracellular signal transduction
- positive regulation of peptidyl-serine phosphorylation
- regulation of excitatory postsynaptic membrane potential
- positive regulation of protein localization at cell surface
- positive regulation of organ growth
- insulin-like growth factor receptor signaling pathway
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- protein import into nucleus
- cellular response to epidermal growth factor stimulus
- negative regulation of macroautophagy
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of lymphocyte migration
- cellular response to reactive oxygen species
- cell proliferation
- positive regulation of nitric oxide biosynthetic process
- insulin receptor signaling pathway
- regulation of mRNA stability
- positive regulation of transcription from RNA polymerase II promoter
- execution phase of apoptosis
- maternal placenta development
- positive regulation of smooth muscle cell proliferation
- regulation of translation
- response to heat
- protein kinase B signaling cascade
- striated muscle cell differentiation
- cytokine-mediated signaling pathway
- behavioral response to pain
- cellular response to cadmium ion
- osteoblast differentiation
- positive regulation of endothelial cell migration
- interleukin-18-mediated signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- T cell costimulation
- negative regulation of release of cytochrome c from mitochondria
- response to growth hormone stimulus
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of blood vessel endothelial cell migration
- positive regulation of lipid biosynthetic process
- glycogen biosynthetic process
- regulation of glycogen biosynthetic process
- positive regulation of protein phosphorylation
- positive regulation of sodium ion transport
- positive regulation of endothelial cell proliferation
- cellular response to vascular endothelial growth factor stimulus
- fibroblast migration
- positive regulation of fibroblast migration
- response to food
- oogenesis stage
- epidermal growth factor receptor signaling pathway
- protein autophosphorylation
- positive regulation of fat cell differentiation
- cell migration involved in sprouting angiogenesis
- glucose metabolic process
- negative regulation of protein binding
- sphingosine-1-phosphate signaling pathway
- positive regulation of glycogen biosynthetic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- evasion of host defenses by virus
- regulation of neuron projection development
- negative regulation of protein ubiquitination
- positive regulation of protein localization to nucleus
- positive regulation of cyclin-dependent protein kinase activity
- G-protein coupled receptor signaling pathway
- NIK/NF-kappaB cascade
- anoikis
- regulation of apoptotic process
- activation-induced cell death of T cells
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of glucose metabolic process
- labyrinthine layer blood vessel development
- positive regulation of gene expression
- negative regulation of autophagy
- negative regulation of plasma membrane long-chain fatty acid transport
- glucose homeostasis
- maintenance of protein location in mitochondrion
- gene expression
- lipopolysaccharide-mediated signaling pathway
- establishment of protein localization in mitochondrion
- positive regulation of endodeoxyribonuclease activity
- nitric oxide biosynthetic process
- peptidyl-serine phosphorylation
- regulation of cell migration
- peptidyl-threonine phosphorylation
- protein ubiquitination
- positive regulation of cell migration
- negative regulation of proteolysis
- protein phosphorylation
- negative regulation of Notch signaling pathway
- negative regulation of protein kinase activity
- cellular response to insulin stimulus
- response to oxidative stress
- response to UV-A
- apoptotic mitochondrial changes
- negative regulation of endopeptidase activity
- cellular response to tumor necrosis factor
- phosphorylation
- response to fluid shear stress
- positive regulation of G1/S transition of mitotic cell cycle
- signal transduction
- regulation of type B pancreatic cell development
- positive regulation of glucose import
- TOR signaling cascade
- negative regulation of apoptotic process
- cell differentiation
- regulation of myelination
- negative regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cilium basal body
- plasma membrane
- nucleoplasm
- nucleus
- mitochondrial intermembrane space
- cell-cell junction
- cytoplasm
- cell cortex
- membrane
- spindle
- vesicle
- cytosol
- macromolecular complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein serine/threonine kinase inhibitor activity
- protein homodimerization activity
- protein kinase activity
- phosphatidylinositol-3,4-bisphosphate binding
- protein serine/threonine kinase activity
- phosphatidylinositol-3,4,5-trisphosphate binding
- ATP binding
- calmodulin binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- nitric-oxide synthase regulator activity
- kinase activity
- 14-3-3 protein binding
- enzyme binding