Yme1l1 Gene Summary [Rat]
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | Yme1l1 |
| Official Name | YME1-like 1 ATPase [Source:RGD Symbol;Acc:620764] |
| Ensembl ID | ENSRNOG00000017100 |
| Bio databases IDs | |
| Aliases | YME1-like 1 ATPase |
| Synonyms | FTSH, FtsH1, LOC108348078, MEG4, OPA11, PAMP, YME1L, YME1-like 1 ATPase, YME1-like 1 (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Yme1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- peptidase
- Peptidase family M41
- protein binding
- ATP-dependent peptidase
- ATP-dependent metalloprotease FtsH
- AAA+ lid domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- optic atrophy type 11
- non-small cell lung cancer
- neoplasia
- gastric cancer
- idiopathic scoliosis
role in cell
- phosphorylation in
- morphology
- proliferation
- migration
- response
- apoptosis
- depolarization
- depolarization in
- growth
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Yme1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- mitochondrial protein catabolic process
- misfolded or incompletely synthesized protein catabolic process
- positive regulation of mitochondrial fusion
- negative regulation of apoptotic process
- protein hexamerization
- regulation of stem cell division
- mitochondrial protein processing
- cellular response to starvation
- neuronal stem cell maintenance
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nuclear body
- membrane
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- metal ion binding
- ATP-dependent peptidase activity
- metalloendopeptidase activity