Smarce1 Gene Summary [Rat]
Predicted to enable N-acetyltransferase activity; RNA binding activity; and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription and spermatid development. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 5; familial meningioma; and meningioma. Orthologous to human SMARCE1 (SWI/SNF related BAF chromatin remodeling complex subunit E1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Smarce1 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Source:RGD Symbol;Acc:1304726] |
| Ensembl ID | ENSRNOG00000010676 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
| Synonyms | 2810417B20Rik, 5830412H02RIK, 9030408N19Rik, Baf27, BAF57, CSS5, RGD1304726, SWI/SNF related BAF chromatin remodeling complex subunit E1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smarce1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHRLI domain
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- high mobility group (HMG)-box domain superfamily
- nuclear localization sequence
- chromatin binding
- coiled-coil domain
- protein binding
- acidic domain
- proline rich domain
- RNA binding
- N-acetyltransferase
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
Pathways
Biological processes and signaling networks where the Smarce1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- susceptibility to familial meningioma
- hereditary disorder
- Coffin-Siris syndrome type 5
- hereditary cancer-predisposing syndrome
- familial meningioma
- meningeal neoplasia
role in cell
- proliferation
- differentiation
- morphology
- growth
- apoptosis
- expression in
- colony formation
- activation in
- contact growth inhibition
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- chromosome
- nucleoplasm
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smarce1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- positive regulation of cell differentiation
- neurogenesis
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nuclear chromosome
- brahma complex
- kinetochore
- chromatin
- nucleoplasm
- nucleus
- npBAF complex
- nuclear matrix
- macromolecular complex
- nBAF complex
- RSC complex
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- RNA binding
- protein binding
- transcription coactivator activity
- nucleosomal DNA binding
- chromatin binding
- N-acetyltransferase activity