Pmpcb Gene Summary [Rat]
Enables metalloendopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pmpcb |
| Official Name | peptidase, mitochondrial processing beta subunit [Source:RGD Symbol;Acc:621297] |
| Ensembl ID | ENSRNOG00000012693 |
| Bio databases IDs | |
| Aliases | peptidase, mitochondrial processing beta subunit |
| Synonyms | 3110004O18RIK, Beta-MPP, MAS1, Mpp, MPP11, MPPB, MPPP52, P-52, peptidase (mitochondrial processing) beta, peptidase, mitochondrial processing subunit beta, peptidase, mitochondrial processing subunit β, peptidase (mitochondrial processing) β, β-MPP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pmpcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- endopeptidase
- peptidase
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Pmpcb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- multiple mitochondrial dysfunctions syndrome type 6
- hereditary disorder
- ulcerative colitis
- age-related hearing loss
role in cell
- transport in
- processing in
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pmpcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein processing involved in protein targeting to mitochondrion
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial processing peptidase complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metalloendopeptidase activity