Slc2a4 Gene Summary [Rat]
Enables D-glucose uniporter activity. Involved in several processes, including cellular response to hypoxia; glucose import in response to insulin stimulus; and regulation of synaptic vesicle budding from presynaptic endocytic zone membrane. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a4 |
| Official Name | solute carrier family 2 member 4 [Source:RGD Symbol;Acc:2711] |
| Ensembl ID | ENSRNOG00000017226 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 4 |
| Synonyms | Gef, GLUT4, GT2, Insulin-responsive glucose transporter, solute carrier family 2 (facilitated glucose transporter), member 4, solute carrier family 2 member 4, twgy |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc2a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- intracellular loop
- insulin-responsive hydrogen:glucose transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- central domain
- phosphate:H+ symporter
- protein binding
- endocytic signal motif
- cytoplasmic domain
- Sugar (and other) transporter
- cytoplasmic loop
- glucose uniporter
- lumenal domain
- extracellular loop
- transporter
Pathways
Biological processes and signaling networks where the Slc2a4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-small cell lung cancer
- bipolar disorder
- schizophrenia
- schizoaffective disorder
- impaired glucose tolerance
- bipolar I disorder
- insulin resistance
- psychosis
- morbid obesity
role in cell
- expression in
- activation
- proliferation
- phosphorylation in
- apoptosis
- cell death
- growth
- survival
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- exocytotic vesicle fractions
- microsomal fraction
- plasma membrane fraction
- high-density microsomal fractions
- intracellular membrane fractions
- nuclear fraction
- membrane vesicles
- endosomal fractions
- Golgi-endosome fractions
- low-density microsomal fraction
- membrane fraction
- endosomal membrane fractions
- cytoplasmic vesicle membrane
- endomembrane system
- intracellular compartment
- Cytoplasm
- presynaptic regions
- cell surface
- perinuclear membrane
- cell periphery
- intracellular space
- perinuclear region
- pericentriolar regions
- intracellular membranes
- cellular membrane
- vacuole
- intracellular storage compartment
- endosomes
- sarcoplasmic reticulum
- vesicles
- Golgi Apparatus
- microtubules
- granules
- cytosol
- vesicle membrane
- microsome
- plasma membrane extracellular face
- caveolae
- trans face of the Golgi apparatus
- trans Golgi network
- endosomal compartment
- perinuclear space
- myofibrils
- I band
- terminal cisternae
- I-A band junctions
- A bands
- sarcolemma
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- GLUT4 vesicles
- multivesicular bodies
- transverse tubules
- secretory granules
- microsomal membrane
- Golgi cisternae
- membrane rafts
- clathrin-coated pits
- perikaryon
- sorting endosomes
- exosomes
- clathrin-coated vesicles
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc2a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amylopectin biosynthetic process
- dehydroascorbic acid transport
- glucose import
- learning or memory
- long-term memory
- cellular response to insulin stimulus
- carbohydrate metabolic process
- brown fat cell differentiation
- response to ethanol
- short-term memory
- cellular response to osmotic stress
- glucose import in response to insulin stimulus
- white fat cell proliferation
- glucose homeostasis
- cellular response to tumor necrosis factor
- positive regulation of brain-derived neurotrophic factor receptor signaling pathway
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- insulin-responsive compartment
- sarcoplasmic reticulum
- trans-Golgi network transport vesicle
- external side of plasma membrane
- multivesicular body
- plasma membrane
- T-tubule
- trans-Golgi network
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- coated pit
- vesicle membrane
- sarcolemma
- membrane raft
- membrane
- cytosol
- endomembrane system
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- D-glucose transmembrane transporter activity
- glucose transmembrane transporter activity
- glucose uniporter activity