Creb3 Gene Summary [Rat]
Predicted to enable several functions, including CCR1 chemokine receptor binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and cAMP response element binding protein binding activity. Predicted to be involved in several processes, including positive regulation of chemotaxis; positive regulation of deacetylase activity; and positive regulation of defense response to virus by host. Predicted to be located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human CREB3 (cAMP responsive element binding protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Creb3 |
| Official Name | cAMP responsive element binding protein 3 [Source:RGD Symbol;Acc:1308831] |
| Ensembl ID | ENSRNOG00000016452 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein 3 |
| Synonyms | cAMP responsive element binding protein 3, CREBP3, LUMAN, LZIP, LZIP-1, LZIP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Creb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- cAMP response element binding protein binding
- CCR chemokine receptor binding
- nucleic acid binding
- Basic region leucine zipper
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Creb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Calcium Signaling
- Corticotropin Releasing Hormone Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Ephrin Receptor Signaling
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Synaptic Long Term Potentiation
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- prostatic neoplasm
- kidney disease
- migraines
- prostatic neoplasia
role in cell
- expression in
- apoptosis
- replication in
- growth
- migration
- proliferation
- invasion by
- downregulation in
- chemotaxis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- nuclear bodies
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Creb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- endoplasmic reticulum unfolded protein response
- positive regulation of monocyte chemotaxis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- endoplasmic reticulum
- Golgi membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity