Bcl2l2 Gene Summary [Rat]
Enables BH domain binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and cellular response to glycine. Located in cytosol and mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l2 |
| Official Name | Bcl2-like 2 [Source:RGD Symbol;Acc:620717] |
| Ensembl ID | ENSRNOG00000015732 |
| Bio databases IDs | |
| Aliases | Bcl2-like 2 |
| Synonyms | BCL2-like 2, BCL-W, BCL-WEL, BCL-WS, c98, Gtrgal2, Gtrosa41, PPP1R51 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcl2l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- apoptosis regulator
- Bcl-2 homology region 4
- binding protein
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- PP1 binding domain
- protein domain specific binding
- protein binding
- loop domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- primary myelofibrosis
- hypoplasia
- breast cancer
- bladder cancer
- post polycythemia vera myelofibrosis
- post essential thrombocythemia myelofibrosis
- leukemogenesis
- myelofibrosis
- nevus
role in cell
- quantity
- proliferation
- cell death
- apoptosis
- permeabilization
- transmembrane potential
- survival
- degeneration
- stabilization
- degeneration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial membrane
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcl2l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Sertoli cell proliferation
- negative regulation of mitochondrial membrane permeability
- negative regulation of release of cytochrome c from mitochondria
- spermatogenesis
- regulation of apoptotic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- extrinsic apoptotic signaling pathway in absence of ligand
- cellular response to estradiol stimulus
- response to ischemia
- negative regulation of apoptotic process
- release of cytochrome c from mitochondria
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- Bcl-2 family protein complex
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- identical protein binding
- protein binding