Pld3 Gene Summary [Rat]
Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in myotube differentiation and regulation of cytokine production involved in inflammatory response. Predicted to be located in bounding membrane of organelle; endoplasmic reticulum membrane; and lysosomal lumen. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to human PLD3 (phospholipase D family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pld3 |
| Official Name | phospholipase D family, member 3 [Source:RGD Symbol;Acc:1308248] |
| Ensembl ID | ENSRNOG00000018390 |
| Bio databases IDs | |
| Aliases | phospholipase D family, member 3 |
| Synonyms | AD19, HU-K4, phospholipase D family member 3, phospholipase D family, member 3, Sam-9, SCA46 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pld3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phospholipase D Active site motif
- phospholipase D
- PLD-like domain
- enzyme
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- single-stranded DNA specific 5'-3' exodeoxyribonuclease
Pathways
Biological processes and signaling networks where the Pld3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- uterine leiomyoma
- leiomyomatosis
- spinocerebellar ataxia type 46
role in cell
- expression in
- quantity
- differentiation
- proliferation
- number
- formation
- G2/M phase
- accumulation
- leakiness
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- lysosomal compartment
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pld3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- myotube differentiation
- regulation of cytokine production involved in inflammatory response
- DNA metabolic process
- immune system process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endoplasmic reticulum membrane
- late endosome membrane
- extracellular vesicular exosome
- lysosomal lumen
- Golgi membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
- phospholipase D activity