St3gal6 Gene Summary [Rat]
Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in cellular response to interleukin-6; glycolipid biosynthetic process; and protein glycosylation. Predicted to be located in Golgi membrane. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal6 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [Source:RGD Symbol;Acc:1303279] |
| Ensembl ID | ENSRNOG00000001653 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| Synonyms | 1700023B24Rik, alpha-2,3-sialyltransferase VI, Sialyltransferase 10, SIAT10, ST3 beta-galactoside alpha-2,3-sialyltransferase 6, ST3GALVI, ST3 β-galactoside α-2,3-sialyltransferase 6, α-2,3-sialyltransferase VI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat St3gal6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- N-acetyllactosaminide alpha-2,3-sialyltransferase
- sialyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- epithelial basal cell carcinoma
- diabetic nephropathy
- thrombocytopenia
regulates
- glycolipid
- glycoprotein
- keratan sulfate
- oligosaccharide
- neolactohexaosylceramide
- paragloboside
role in cell
- number
- migration
- recruitment
- volume
- cell tethering or rolling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat St3gal6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to interleukin-6
- protein glycosylation
- glycolipid biosynthetic process
- oligosaccharide biosynthetic process
- keratan sulfate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
- sialyltransferase activity