Ttc25 Gene Summary [Rat]
Predicted to be involved in mucociliary clearance and protein localization to motile cilium. Predicted to act upstream of or within cerebrospinal fluid circulation; epithelial cilium movement involved in determination of left/right asymmetry; and outer dynein arm assembly. Predicted to be located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Predicted to be part of outer dynein arm docking complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttc25 |
| Official Name | tetratricopeptide repeat domain 25 [Source:RGD Symbol;Acc:1311859] |
| Ensembl ID | ENSRNOG00000017473 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 25 |
| Synonyms | 4933404O19Rik, outer dynein arm complex subunit 4, outer dynein arm docking complex subunit 4, RGD1311859, TTC25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttc25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttc25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- epithelial cilium movement involved in determination of left/right asymmetry
- outer dynein arm assembly
- brain development
- cilium movement
- lung development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding