Myog Gene Summary [Rat]
This gene belongs to the myogenic factor subfamily of the basic helix-loop-helix (BHLH) family of transcription factors. The protein encoded by this gene is a muscle-specific skeletal myogenin, which acts in concert with other family members to regulate myogenesis. The protein plays an essential role in the conversion of undifferentiated cells to myoblasts and functional skeletal muscle. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Myog |
| Official Name | myogenin [Source:RGD Symbol;Acc:620432] |
| Ensembl ID | ENSRNOG00000030743 |
| Bio databases IDs | |
| Aliases | myogenin |
| Synonyms | bHLHc3, MG, MYF4, Myg, myo, myogenic factor 4, Myogenin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myog often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- transcription activation domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- Myogenic Basic domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- basic domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lack of spontaneous movement
- sporadic amyotrophic lateral sclerosis
- myotonic dystrophy type 2
- kyphosis
- hypoplasia
- facioscapulohumeral muscular dystrophy
- amyotrophic lateral sclerosis
- myotonic dystrophy type 1
- muscular atrophy
- respiratory failure
role in cell
- expression in
- phosphorylation in
- proliferation
- cell cycle progression
- differentiation
- growth
- fusion
- development
- quantity
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myog gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity involved in regulation of muscle adaptation
- response to denervation involved in regulation of muscle adaptation
- striated muscle atrophy
- negative regulation of cell proliferation
- muscle cell fate commitment
- positive regulation of myoblast differentiation
- positive regulation of skeletal muscle fiber development
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to lithium ion
- cellular response to estradiol stimulus
- skeletal muscle cell differentiation
- skeletal muscle fiber development
- ossification
- cellular response to growth factor stimulus
- skeletal muscle tissue development
- positive regulation of myotube differentiation
- positive regulation of muscle atrophy
- cellular response to tumor necrosis factor
- response to electrical stimulus involved in regulation of muscle adaptation
- regulation of cell cycle
- regulation of satellite cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity