Cfap53 Gene Summary [Rat]
Predicted to be involved in determination of left/right symmetry; manchette assembly; and sperm flagellum assembly. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and protein localization to motile cilium. Predicted to be located in several cellular components, including ciliary transition zone; microtubule cytoskeleton; and motile cilium. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. Human ortholog(s) of this gene implicated in visceral heterotaxy 6. Orthologous to human CFAP53 (cilia and flagella associated protein 53). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfap53 |
| Official Name | cilia and flagella associated protein 53 [Source:RGD Symbol;Acc:1306734] |
| Ensembl ID | ENSRNOG00000014585 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 53 |
| Synonyms | 4933415I03Rik, CCDC11, cilia and flagella associated protein 53, HTX6, RGD1306734 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfap53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trichohyalin-plectin-homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary transition zone
- cilia
- manchette
- centrosome
- axonemes
- spindle pole
- sperm tail
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfap53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cilium movement involved in determination of left/right asymmetry
- cilium morphogenesis
- cilium movement
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- axonemal microtubule
- centriole
- centriolar satellite
- spindle pole
- ciliary transition zone
- extracellular region
- sperm flagellum
- manchette
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding