Odad4 Gene Summary [Mouse]
Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; lung development; and outer dynein arm assembly. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Is expressed in node. Used to study primary ciliary dyskinesia 35. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Odad4 |
| Official Name | outer dynein arm complex subunit 4 [Source:MGI Symbol;Acc:MGI:1921657] |
| Ensembl ID | ENSMUSG00000006784 |
| Bio databases IDs | |
| Aliases | outer dynein arm complex subunit 4 |
| Synonyms | 4933404O19Rik, outer dynein arm complex subunit 4, outer dynein arm docking complex subunit 4, RGD1311859, TTC25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Odad4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- axonemes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Odad4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- epithelial cilium movement involved in determination of left/right asymmetry
- outer dynein arm assembly
- brain development
- cilium movement
- lung development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding