Abi2

Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; lens fiber cell morphogenesis; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including dendrite development; learning or memory; and peptidyl-tyrosine phosphorylation. Predicted to be located in several cellular components, including actin filament; dendrite; and filopodium tip. Predicted to be part of SCAR complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and postsynaptic actin cytoskeleton. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Abi2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Abi2 gene, providing context for its role in the cell.