ABI2 Gene Summary [Human]
Enables several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including filopodium tip; lamellipodium; and nucleoplasm. Part of SCAR complex. Is active in adherens junction. Colocalizes with actin filament. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ABI2 |
| Official Name | abl interactor 2 [Source:HGNC Symbol;Acc:HGNC:24011] |
| Ensembl ID | ENSG00000138443 |
| Bio databases IDs | |
| Aliases | abl interactor 2 |
| Synonyms | 8430425M24Rik, Abelson interactor 2, ABI2B, Abl binding protein 3, AblBP3, abl-interactor 2, AIP-1, ARG binding, ArgBP1, argBPIA, argBPIB, ARGININE TYROSINE KINASE binding, C130078H13, LOC100365983, LOC301448, SSH3BP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Abl-interactor HHR
- protein binding activity, bridging
- enzyme binding
- protein binding
- identical protein binding
- proline rich domain
- SH3-domain binding
- cytoskeletal adaptor
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the ABI2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microphthalmia
- coronary artery disease
- uterine leiomyoma
- leiomyomatosis
- chronic pain
role in cell
- migration
- proliferation
- development
- morphogenesis
- assembly
- abnormal morphology
- function
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cytoskeleton
- actin cytoskeleton
- actin filaments
- cytosol
- nucleoplasm
- dendritic spines
- filopodia
- dendrites
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- positive regulation of lamellipodium assembly
- Rac protein signal transduction
- peptidyl-tyrosine phosphorylation
- neuron migration
- lens fiber cell morphogenesis
- cytoskeleton organization
- actin polymerization or depolymerization
- positive regulation of Arp2/3 complex-mediated actin nucleation
- macromitophagy
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- SCAR complex
- adherens junction
- cytoskeleton
- cytoplasm
- dendritic spine
- cytosol
- filopodium tip
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- cytoskeletal adaptor activity
- signaling adaptor activity
- small GTPase binding
- SH3 domain binding
- kinase binding