Arl6ip1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cotranslational protein targeting to membrane; endoplasmic reticulum tubular network organization; and positive regulation of L-glutamate import across plasma membrane. Predicted to be located in cytosol and endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Predicted to be active in endoplasmic reticulum tubular network and membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ARL6 interacting reticulophagy regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl6ip1 |
| Official Name | ADP-ribosylation factor like GTPase 6 interacting protein 1 [Source:RGD Symbol;Acc:735205] |
| Ensembl ID | ENSRNOG00000017751 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor like GTPase 6 interacting protein 1 |
| Synonyms | ADP-ribosylation factor-like 6 interacting protein 1, AIP1, AIP-6, ARL6 interacting reticulophagy regulator 1, ARL6IP, ARMER, Clone MGC:5360, KIAA0069, mKIAA0069, SPG61 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arl6ip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- Arl6IP1_RETR3-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive spastic paraplegia type 61
- postural deformity of limb
- gait disturbance
- hereditary spastic paraplegia
role in cell
- expression in
- quantity
- apoptosis
- number
- cell death
- formation
- autophagy
- autophagy in
- mitophagy in
- expansion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- mitochondria-associated membranes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arl6ip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of L-glutamate transport
- cotranslational protein targeting to membrane
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- apoptotic process
- endoplasmic reticulum tubular network assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum tubular network
- membrane
- cytosol
- endoplasmic reticulum
- Sec61 translocon complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding