Ca12 Gene Summary [Rat]
Predicted to enable carbonate dehydratase activity. Involved in estrous cycle. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ca12 |
| Official Name | carbonic anhydrase 12 [Source:RGD Symbol;Acc:1306612] |
| Ensembl ID | ENSRNOG00000017766 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 12 |
| Synonyms | 2310047E01Rik, Car12, carbonic anhydrase 12, CA-XII, FLJ20151, HsT18816, T18816 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ca12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- keratitis
- acne vulgaris
- infectious conjunctivitis
- chronic anterior uveitis
- corneal injury
- infection
- palpebral conjunctivitis
- Escherichia coli infection
- bulbar conjunctivitis
- anterior segment inflammation
regulates
role in cell
- growth
- migration
- invasion by
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ca12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chloride ion homeostasis
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- carbonate dehydratase activity