Ercc1 Gene Summary [Rat]
Predicted to enable DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including response to cadmium ion; response to immobilization stress; and response to sucrose. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Predicted to be active in nucleus. Used to study lung carcinoma. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ercc1 |
| Official Name | ERCC excision repair 1, endonuclease non-catalytic subunit [Source:RGD Symbol;Acc:1306992] |
| Ensembl ID | ENSRNOG00000017839 |
| Bio databases IDs | |
| Aliases | ERCC excision repair 1, endonuclease non-catalytic subunit |
| Synonyms | COFS4, ERCC excision repair 1, endonuclease non-catalytic subunit, excision repair cross-complementing rodent repair deficiency, complementation group 1, RAD10, UV20 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ercc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- DNA repair protein rad10
- central domain
- transcription factor binding
- Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
- chromatin binding
- enzyme
- protein binding
- Helix-hairpin-helix motif
- PDDEXK family nucleases
- single-stranded DNA specific endodeoxyribonuclease
- nuclease domain of XPF/MUS81 family proteins
- DNA binding
- binding protein
- damaged DNA binding
- single-stranded DNA binding
Pathways
Biological processes and signaling networks where the Ercc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebrooculofacioskeletal syndrome 4
- learning deficit
- androgenic alopecia
- dystonia
- gastroesophageal reflux
- ataxia
- growth failure
- neurological disorder
- Dukes stage C colorectal cancer
- hepatic steatosis
role in cell
- formation
- binding in
- apoptosis
- loss
- cell viability
- proliferation
- formation in
- number
- abnormal morphology
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic aggregates
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ercc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- multicellular organism growth
- DNA repair
- post-embryonic hemopoiesis
- response to X-ray
- male gonad development
- replicative senescence
- positive regulation of transcription initiation from RNA polymerase II promoter
- UV protection
- determination of adult lifespan
- nucleotide-excision repair
- double-strand break repair via nonhomologous end joining
- response to oxidative stress
- negative regulation of telomere maintenance
- isotype switching
- UV-damage excision repair
- spermatogenesis
- insulin-like growth factor receptor signaling pathway
- embryonic organ development
- response to cadmium ion
- response to nutrient
- pyrimidine dimer repair by nucleotide-excision repair
- mitotic recombination
- response to sucrose stimulus
- syncytium formation
- oogenesis
- response to immobilization stress
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleotide-excision repair factor 1 complex
- cytoplasm
- nucleotide-excision repair complex
- ERCC4-ERCC1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- TFIID-class transcription factor binding
- damaged DNA binding
- single-stranded DNA specific endodeoxyribonuclease activity
- single-stranded DNA binding