Rad52 Gene Summary [Rat]
Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; and mitotic recombination. Predicted to act upstream of or within DNA double-strand break processing involved in repair via single-strand annealing; cellular response to oxidative stress; and regulation of nucleotide-excision repair. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad52 |
| Official Name | RAD52 homolog, DNA repair protein [Source:RGD Symbol;Acc:1304975] |
| Ensembl ID | ENSRNOG00000009742 |
| Bio databases IDs | |
| Aliases | RAD52 homolog, DNA repair protein |
| Synonyms | LOC100130219, RAD52 homolog, DNA repair protein, Rad52yh |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rad52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- self-association domain
- DNA binding domain
- single-stranded DNA binding
- RAD51 binding domain
- replication protein A binding domain
- Rad52/22 family double-strand break repair protein
- protein binding
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Rad52 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-Hodgkin disease
- cancer
- small cell lung carcinoma
- small cell lung cancer
- T-cell non-Hodgkin disease
- T cell cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- accumulation in
- proliferation
- growth
- quantity
- survival
- abnormal morphology
- DNA damage response
- formation
- accumulation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rad52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA double-strand break processing involved in repair via single-strand annealing
- double-strand break repair via single-strand annealing
- double-strand break repair via homologous recombination
- DNA recombination
- cellular response to oxidative stress
- regulation of nucleotide-excision repair
- DNA recombinase assembly
- mitotic recombination
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- protein-DNA complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- single-stranded DNA binding