Acsl4 Gene Summary [Rat]
Enables arachidonate-CoA ligase activity. Involved in several processes, including dendritic spine development; lipid biosynthetic process; and positive regulation of insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsl4 |
| Official Name | acyl-CoA synthetase long-chain family member 4 [Source:RGD Symbol;Acc:69401] |
| Ensembl ID | ENSRNOG00000019180 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase long-chain family member 4 |
| Synonyms | 9430020A05Rik, ACS4, acyl-CoA synthetase long-chain family member 4, arachidonoyl-CoA synthetase, FACL4, LACS4, Long-Chain Acyl-CoA Synthetase 4, MRX63, MRX68, XLID63 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain-fatty-acid-CoA ligase
- fatty-acid ligase
- arachidonate-CoA ligase
- benzoate-CoA ligase family
- AMP-binding enzyme
- CoA-ligase
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- Adenylate forming domain, Class I superfamily
- enzyme
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsl4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- hepatic fibrosis
- fibrosis
role in cell
- quantity
- apoptosis
- survival
- cell death
- expression in
- phosphorylation in
- degradation in
- migration
- proliferation
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- endoplasmic reticulum membrane
- microsome
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial outer membrane
- peroxisomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid metabolic process
- neuron differentiation
- lipid metabolic process
- long-chain fatty-acyl-CoA biosynthetic process
- positive regulation of insulin secretion
- embryonic process involved in female pregnancy
- fatty acid metabolic process
- long-chain fatty-acyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- lipid particle
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoplasm
- membrane
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- very long-chain fatty acid-CoA ligase activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity