Nars1 Gene Summary [Rat]
Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nars1 |
| Official Name | asparaginyl-tRNA synthetase 1 [Source:RGD Symbol;Acc:1307238] |
| Ensembl ID | ENSRNOG00000017852 |
| Bio databases IDs | |
| Aliases | asparaginyl-tRNA synthetase 1 |
| Synonyms | 3010001M15Rik, ASNRS, Asn tRNA Synthetase, asparaginyl-tRNA synthetase 1, KS, LRRGT00113, NARS, NEDMILEG, NEDMILG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nars1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- class_II_aaRS-like_core
- OB-fold nucleic acid binding domain
- CCR chemokine receptor binding
- tRNA synthetases class II (D, K and N)
- asparagine-tRNA ligase
- enzyme
- protein binding
- asparaginyl-tRNA synthetase
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder
- neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities
- neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities
- lymphomagenesis
- lymphoma
- developmental disorder
- nuclear type 35 mitochondrial complex I deficiency
regulates
- tRNA-asn
- MTORC1
role in cell
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nars1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- asparaginyl-tRNA aminoacylation
- cerebral cortex development
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ATP binding
- protein binding
- asparagine-tRNA ligase activity
- CCR3 chemokine receptor binding
- protein dimerization activity