Srsf1 Gene Summary [Rat]
Enables protein kinase B binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; liver regeneration; and positive regulation of RNA splicing. Located in nuclear envelope. Used to study myocardial infarction. Biomarker of hepatocellular carcinoma and renovascular hypertension. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities. Orthologous to human SRSF1 (serine and arginine rich splicing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srsf1 |
| Official Name | serine and arginine rich splicing factor 1 [Source:RGD Symbol;Acc:1587490] |
| Ensembl ID | ENSRNOG00000050323 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 1 |
| Synonyms | 1110054N12Rik, 5730507C05RIK, 6330415C05Rik, ASF, ASF/SF2, FLJ44342, LOC102554532, LOC124907953, LOC688114, NEDFBA, RP11 159D125, serine and arginine-rich splicing factor 1, SF2, SF2/ASF, SF2p33, SFRS1, SRp30a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srsf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RS domain binding
- protein kinase binding
- RNA recognition motif
- mRNA binding
- enzyme binding
- Occluded RNA-recognition motif
- protein binding
- SR domain
- RNA-binding domain
- RNA binding
Pathways
Biological processes and signaling networks where the Srsf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities
- hereditary disorder
- non-small cell lung cancer
- lung cancer
- pituitary gland adenoma
- adenoma formation
role in cell
- cell death
- apoptosis
- production in
- quantity
- expression in
- proliferation
- binding in
- damage in
- phosphorylation in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- spliceosomes
- nuclear foci
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear envelope
- nuclear speckles
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srsf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- nuclear mRNA 5'-splice site recognition
- alternative nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- positive regulation of RNA splicing
- mRNA splice site selection
- mRNA processing
- mRNA transport
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- exon-exon junction complex
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- protein kinase B binding
- DNA topoisomerase binding