Rere Gene Summary [Rat]
Predicted to enable transcription coactivator activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin remodeling and nervous system development. Predicted to be located in nuclear body. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rere |
| Official Name | arginine-glutamic acid dipeptide repeats [Source:RGD Symbol;Acc:629475] |
| Ensembl ID | ENSRNOG00000017940 |
| Bio databases IDs | |
| Aliases | arginine-glutamic acid dipeptide repeats |
| Synonyms | 1110033A15RIK, AI414665, ARG, arginine-glutamic acid dipeptide repeats, arginine glutamic acid dipeptide (RE) repeats, ARP, ATN1L, Atr2, DNB1, eye<m03Jus>, eyes3, mKIAA0458, NEDBEH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rere often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription co-activator
- Atrophin-1 family
- transcription co-repressor
- Serine-rich region of AP3B1, clathrin-adaptor complex
- protein binding
- BAH
- BAH domain
- ELM2 domain
- Myb-like DNA-binding domain
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- zinc finger domain
- ZnF_GATA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- meningitis
- atopic dermatitis
- schizophrenia
- neurodevelopmental disorder with or without anomalies of the brain, eye, or heart
- neck pain
- allergy
- cardiac fibrosis
- asthma
regulates
role in cell
- migration
- phosphorylation in
- quantity
- morphogenesis
- remodeling
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- invadopodia
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rere gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar Purkinje cell layer maturation
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- cerebellar granule cell precursor proliferation
- branching morphogenesis of a nerve
- radial glia guided migration of Purkinje cell
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding
- transcription corepressor activity
- sequence-specific DNA binding
- chromatin binding