Lztr1 Gene Summary [Rat]
Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and protein ubiquitination. Predicted to be located in Golgi apparatus and recycling endosome membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lztr1 |
| Official Name | leucine-zipper-like transcription regulator 1 [Source:RGD Symbol;Acc:1309100] |
| Ensembl ID | ENSRNOG00000001870 |
| Bio databases IDs | |
| Aliases | leucine-zipper-like transcription regulator 1 |
| Synonyms | 1200003E21Rik, BTBD29, leucine zipper like post translational regulator 1, leucine-zipper-like transcriptional regulator, 1, NS10, NS2, SWNTS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lztr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- enzyme binding
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- hepatocellular carcinoma
- Noonan syndrome type 10
- Noonan spectrum disorder
- Noonan syndrome
- schwannomatosis type 2
- liver cancer
- epithelial cancer
- Noonan syndrome type 2
- central nervous system cancer
regulates
- zymosan
- Myelin
role in cell
- apoptosis
- phagocytosis
- phagocytosis by
- palbociclib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endomembrane system
- Golgi Apparatus
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lztr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endomembrane system
- Golgi apparatus
- recycling endosome membrane
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding