Bst1 Gene Summary [Rat]
Predicted to enable NAD+ nucleosidase activity, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of neutrophil chemotaxis; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in uropod. Predicted to be active in plasma membrane. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bst1 |
| Official Name | bone marrow stromal cell antigen 1 [Source:RGD Symbol;Acc:620344] |
| Ensembl ID | ENSRNOG00000003064 |
| Bio databases IDs | |
| Aliases | bone marrow stromal cell antigen 1 |
| Synonyms | 114/A10, A530073F09, bone marrow stromal cell antigen 1, BP-3, Bsta1, cADPR2, CD157, Ly65 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38
- N-glycosyl glycosylase
- enzyme
Pathways
Biological processes and signaling networks where the Bst1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- septic shock
- colon adenocarcinoma
- colon epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- aortic valve calcification
- lung adenocarcinoma formation
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
role in cell
- phosphorylation in
- proliferation
- adhesion
- chemotaxis
- extravasation
- quantity
- morphology
- number
- diapedesis by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- specific granule membrane
- uropod
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of integrin-mediated signaling pathway
- regulation of superoxide metabolic process
- signal transduction
- positive regulation of cell proliferation
- regulation of neutrophil chemotaxis
- regulation of cellular extravasation
- regulation of peptidyl-tyrosine phosphorylation
- regulation of actin cytoskeleton organization
- regulation of cell-matrix adhesion
- humoral immune response
- regulation of inflammatory response
- positive regulation of B cell proliferation
- regulation of calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- uropod
- extracellular region
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- phosphorus-oxygen lyase activity
- transferase activity