Rab6a Gene Summary [Rat]
Enables ATPase activator activity; ATPase binding activity; and GTP binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and protein localization to Golgi membrane. Predicted to act upstream of or within peptidyl-cysteine methylation. Is active in presynapse. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab6a |
| Official Name | RAB6A, member RAS oncogene family [Source:RGD Symbol;Acc:619737] |
| Ensembl ID | ENSRNOG00000018176 |
| Bio databases IDs | |
| Aliases | RAB6A, member RAS oncogene family |
| Synonyms | 2610028L11Rik, RAB6, RAB6A', RAB6A, member RAS oncogene family, Rab6b, RCO4-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- alpha helix
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- myosin binding
- ATPase binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab6a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- organismal death
- Alzheimer disease
- insomnia
- infection by HIV-1
role in cell
- formation
- tubulation
- scattering
- transport
- viral entry
- trafficking
- morphogenesis
- reorganization
- reorganization in
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- golgi/trans-golgi network-rich vesicle fraction
- membrane fraction
- pH resistant lipid raft fraction
- exocytic vesicle
- presynaptic regions
- cellular membrane
- Plasma Membrane
- basal bodies
- vesicles
- centrosome
- Golgi Apparatus
- secretory granule membrane
- granules
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- nucleoplasm
- alpha granules
- acrosome
- spine apparatus
- cytoplasmic vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- minus-end-directed organelle transport along microtubule
- protein localization in Golgi apparatus
- neuron projection development
- retrograde vesicle-mediated transport, Golgi to ER
- antigen processing and presentation
- intra-Golgi vesicle-mediated transport
- peptidyl-cysteine methylation
- early endosome to Golgi transport
- intracellular protein transport
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- acrosomal membrane
- Golgi membrane
- Golgi apparatus
- plasma membrane
- endoplasmic reticulum membrane
- secretory granule membrane
- trans-Golgi network
- endosome to plasma membrane transport vesicle
- extracellular vesicular exosome
- membrane
- endomembrane system
- cytosol
- cytoplasmic vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- GTPase activity
- myosin V binding