Galnt2 Gene Summary [Rat]
Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in positive regulation of immunoglobulin production; protein O-linked glycosylation; and protein maturation. Predicted to be located in Golgi stack and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIt. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galnt2 |
| Official Name | polypeptide N-acetylgalactosaminyltransferase 2 [Source:RGD Symbol;Acc:1310692] |
| Ensembl ID | ENSRNOG00000019143 |
| Bio databases IDs | |
| Aliases | polypeptide N-acetylgalactosaminyltransferase 2 |
| Synonyms | CDG2T, GalNAc-T2, polypeptide N-acetylgalactosaminyltransferase 2, pp-GaNTase 2, Ppgantase t2, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Galnt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- Glycosyl transferase family 2
- Ricin-type beta-trefoil
- stalk region
- polypeptide N-acetylgalactosaminyltransferase
- beta-trefoil_Ricin_MRC-like
- enzyme
- protein binding
- manganese ion binding
- Glycosyltransferase like family 2
- ricin B-type lectin domain, beta-trefoil fold
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- dementia
- schizophrenia
- organismal death
- cervical cancer
- metabolic syndrome X
- congenital disorder of glycosylation type 2t
- coronary artery disease
- acute myeloid leukemia
role in cell
- growth
- migration
- phosphorylation in
- expression in
- proliferation
- invasion by
- quantity
- activation in
- invasion
- shedding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Golgi lumen
- perinuclear region
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Galnt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- protein O-linked glycosylation via serine
- protein O-linked glycosylation via threonine
- protein maturation
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- Golgi cisterna membrane
- membrane
- Golgi membrane
- Golgi apparatus
- extracellular region
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding
- manganese ion binding
- carbohydrate binding
- polypeptide N-acetylgalactosaminyltransferase activity