Htr1a Gene Summary [Rat]
Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and behavioral response to nicotine. Located in axon hillock. Is active in GABA-ergic synapse and presynaptic membrane. Used to study Parkinson's disease; alcohol use disorder; and panic disorder. Biomarker of anxiety disorder; cocaine abuse; nicotine dependence; and subacute delirium. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr1a |
| Official Name | 5-hydroxytryptamine receptor 1A [Source:RGD Symbol;Acc:2845] |
| Ensembl ID | ENSRNOG00000010254 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 1A |
| Synonyms | 5-HT-1A, 5ht1a Inhibitory Autoreceptor, 5HT1A Receptor, 5-HTR1A, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine (serotonin) receptor 1A, ADRB2RL1, ADRBRL1, G-21, Gpcr18, PFMCD, RAT5HT1A, Serotonin 1a receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- palmitoylation site
- intracellular loop
- 5-HT1 receptor
- serotonin receptor
- serotonin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- portal hypertension
- diabetes mellitus
- neoplasia
- mucositis
- anxiety disorder
- metabolic syndrome X
- schizophrenia
- Tourette syndrome
- bipolar disorder
role in cell
- expression in
- phosphorylation in
- inhibition
- activation in
- proliferation
- activation
- mobilization in
- binding
- migration
- stability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- granules
- presynaptic membrane
- basolateral membrane
- axon hillock
- synapse
- membrane rafts
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- serotonin metabolic process
- G-protein coupled receptor signaling pathway
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- positive regulation of cell proliferation
- regulation of serotonin secretion
- synaptic transmission
- serotonin receptor signaling pathway
- gamma-aminobutyric acid signaling pathway
- behavioral fear response
- regulation of behavior
- regulation of hormone secretion
- regulation of dopamine metabolic process
- regulation of vasoconstriction
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity