Dhh Gene Summary [Rat]
Predicted to enable calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including response to estradiol; response to estrogen; and spermatid development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in 46,XY complete gonadal dysgenesis; 46,XY gonadal dysgenesis with minifascicular neuropathy; and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhh |
| Official Name | desert hedgehog signaling molecule [Source:RGD Symbol;Acc:620711] |
| Ensembl ID | ENSRNOG00000053675 |
| Bio databases IDs | |
| Aliases | desert hedgehog signaling molecule |
| Synonyms | desert hedgehog, desert hedgehog signaling molecule, GDMN, GDXYM, HHG-3, SRXY7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hint (Hedgehog/Intein) domain C-terminal region
- intein N-terminal splicing region
- Hint module
- peptidase
- calcium ion binding
- enzyme
- protein binding
- Hedgehog amino-terminal signalling domain
- Hint (Hedgehog/Intein) domain N-terminal region
- transferase
- zinc ion binding
- Hint
- patched binding
Pathways
Biological processes and signaling networks where the Dhh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- azoospermia
- partial 46,XY gonadal dysgenesis with minifascicular neuropathy
- hyperplasia
- sex reversal
- 46,XY sex reversal type 7
- hypoplasia
- pseudohermaphroditism
- cryptorchidism
role in cell
- expression in
- differentiation
- number
- proliferation
- phosphorylation in
- specification
- survival
- quantity
- abnormal morphology
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- spermatid development
- cell-cell signaling
- smoothened signaling pathway
- myelination
- male sex determination
- self proteolysis
- positive regulation of smoothened signaling pathway
- response to estradiol stimulus
- regulation of gene expression
- osteoblast differentiation
- protein autoprocessing
- cell fate specification
- regulation of steroid biosynthetic process
- Leydig cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- calcium ion binding
- peptidase activity
- patched binding