Alx3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic morphogenesis; pattern specification process; and regulation of apoptotic process. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in frontonasal dysplasia 1. Orthologous to human ALX3 (ALX homeobox 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alx3 |
| Official Name | ALX homeobox 3 [Source:RGD Symbol;Acc:1359270] |
| Ensembl ID | ENSRNOG00000018290 |
| Bio databases IDs | |
| Aliases | ALX homeobox 3 |
| Synonyms | ALX homeobox 3, aristaless-like homeobox 3, FND, FND1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pattern specification process
- regulation of apoptotic process
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity