ALX3 Gene Summary [Human]
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ALX3 |
| Official Name | ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449] |
| Ensembl ID | ENSG00000156150 |
| Bio databases IDs | |
| Aliases | ALX homeobox 3 |
| Synonyms | ALX homeobox 3, aristaless-like homeobox 3, FND, FND1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pattern specification process
- regulation of apoptotic process
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity