Dlx6 Gene Summary [Rat]
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Dlx6 |
| Official Name | distal-less homeobox 6 [Source:RGD Symbol;Acc:1561539] |
| Ensembl ID | ENSRNOG00000010822 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 6 |
| Synonyms | distal-less homeobox 6, LOC100365183, RGD1561539 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- transitional cell bladder cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- rectum cancer
- renal clear cell adenocarcinoma
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- urothelial bladder carcinoma
- head and neck squamous cell carcinoma
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- head development
- palate development
- nervous system development
- anatomical structure formation involved in morphogenesis
- regulation of transcription from RNA polymerase II promoter
- epithelial cell differentiation
- embryonic limb morphogenesis
- skeletal system development
- inner ear morphogenesis
- cell differentiation
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity