Myo3a Gene Summary [Rat]
Predicted to enable several functions, including ADP binding activity; calmodulin binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in several processes, including inner ear morphogenesis; positive regulation of filopodium assembly; and sensory perception of sound. Predicted to act upstream of or within inner ear development and protein phosphorylation. Predicted to be located in cytoplasm and filopodium. Predicted to be part of filamentous actin. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 90 and autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo3a |
| Official Name | myosin IIIA [Source:RGD Symbol;Acc:1560083] |
| Ensembl ID | ENSRNOG00000018478 |
| Bio databases IDs | |
| Aliases | myosin IIIA |
| Synonyms | 9030416P08Rik, DFNA90, DFNB30, myosin IIIA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myo3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Protein kinase (unclassified specificity)
- protein kinase
- calmodulin binding
- Myosin and Kinesin motor domain
- Protein tyrosine and serine/threonine kinase
- ADP binding
- microfilament motor protein
- protein binding
- Protein kinase domain
- Myosin head (motor domain)
- kinase
- Serine/Threonine protein kinases, catalytic domain
- actin filament binding
- kinase domain
- Calmodulin-binding motif
- Protein Kinases, catalytic domain
- Myosin
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- autosomal recessive deafness type 30
- familial nonsyndromic hearing impairment
- autosomal dominant deafness type 90
- nonsyndromic hearing impairment
- sporadic age-related sensorineural hearing loss
- autosomal dominant deafness type 30
- sensorineural hearing loss
- acute graft-vs-host disease
role in cell
- formation
- formation in
- extension
- elongation
- length
- assembly
- retraction
- elongation in
- retraction in
- lifespan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin filaments
- cytosol
- stereocilia
- photoreceptor inner segments
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myo3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of actin filament length
- cochlea morphogenesis
- positive regulation of filopodium assembly
- protein autophosphorylation
- visual perception
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytoplasm
- filopodium
- filopodium tip
- photoreceptor inner segment
- filamentous actin
- stereocilium bundle tip
Molecular Function
What the gene product does at the molecular level
- ATP binding
- plus-end directed microfilament motor activity
- calmodulin binding
- protein binding
- actin binding
- protein kinase activity
- ADP binding
- protein serine/threonine kinase activity
- microfilament motor activity