Atp23 Gene Summary [Rat]
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Atp23 |
| Official Name | ATP23 metallopeptidase and ATP synthase assembly factor homolog [Source:RGD Symbol;Acc:1588587] |
| Ensembl ID | ENSRNOG00000045629 |
| Bio databases IDs | |
| Aliases | ATP23 metallopeptidase and ATP synthase assembly factor homolog |
| Synonyms | 1110068E08Rik, 2410012H02Rik, ATP23 metallopeptidase and ATP synthase assembly factor homolog, KUB3, XRCC6BP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- DNA-dependent protein kinase
- Peptidase M76 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intracellular membrane-bounded organelle
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial proton-transporting ATP synthase complex assembly
- mitochondrial protein processing
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- DNA-dependent protein kinase-DNA ligase 4 complex
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA-dependent protein kinase activity
- protein binding
- metal ion binding
- metalloendopeptidase activity