Prkaca Gene Summary [Rat]
Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including peptidyl-serine phosphorylation; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Is active in neuromuscular junction; postsynapse; and presynapse. Biomarker of amphetamine abuse and brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; and primary pigmented nodular adrenocortical disease 4. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkaca |
| Official Name | protein kinase cAMP-activated catalytic subunit alpha [Source:RGD Symbol;Acc:3389] |
| Ensembl ID | ENSRNOG00000005257 |
| Bio databases IDs | |
| Aliases | protein kinase cAMP-activated catalytic subunit alpha |
| Synonyms | A KINASE CATALYTIC subunit, Ampk alpha1, CAFD1, cAK C α, PKA, PKA Alpha, PKAC, PKACA, Pka c subunit, Pka C α, PKA α, PKCA1, PKCD, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, protein kinase cAMP-activated catalytic subunit α, protein kinase, cAMP dependent, catalytic, alpha, protein kinase, cAMP dependent, catalytic, α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkaca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- cAMP-dependent protein kinase
- protein kinase
- protein threonine/tyrosine kinase
- ATP binding
- Protein kinase domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- activation domain
- channel regulator
- Protein kinase (unclassified specificity)
- protein kinase A binding
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- protein domain specific binding
- protein binding
- magnesium ion binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- binding protein
- Protein Kinases, catalytic domain
- PDK-1 binding domain
- manganese ion binding
Pathways
Biological processes and signaling networks where the Prkaca gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- ACTH-independent adrenal Cushing syndrome
- cardioacrofacial dysplasia type 1
- organismal death
- allergic rhinitis
- Alzheimer disease
- benign neoplasia
- cancer
role in cell
- expression in
- phosphorylation in
- assembly
- apoptosis
- mitosis
- formation
- growth
- activation in
- survival
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- nuclear fraction
- raft fractions
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- Golgi region
- perinuclear region
- postsynaptic region
- Nucleus
- Plasma Membrane
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- flagella
- Mitochondria
- axonemes
- cytosol
- primary cilia
- apical membrane
- mitochondrial matrix
- nuclear foci
- nucleoplasm
- nuclear speckles
- sperm midpiece
- sperm tail
- acrosome
- germinal vesicles
- neuromuscular junctions
- growth cone
- synapse
- transverse tubules
- membrane rafts
- dendrites
- mossy fibers
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkaca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal water homeostasis
- regulation of proteasomal protein catabolic process
- protein phosphorylation
- regulation of osteoblast differentiation
- positive regulation of gluconeogenesis
- positive regulation of calcium-mediated signaling
- negative regulation of interleukin-2 production
- sperm capacitation
- cellular response to heat
- neural tube closure
- cellular response to glucagon stimulus
- cellular response to epinephrine stimulus
- cellular response to glucose stimulus
- cellular response to parathyroid hormone stimulus
- cytokine-mediated signaling pathway
- protein kinase A signaling cascade
- regulation of cell cycle
- mesoderm formation
- regulation of tight junction assembly
- positive regulation of insulin secretion
- cell communication by electrical coupling involved in cardiac conduction
- mitochondrial protein catabolic process
- high-density lipoprotein particle assembly
- positive regulation of protein export from nucleus
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- mRNA processing
- protein export from nucleus
- negative regulation of smoothened signaling pathway
- regulation of heart rate
- regulation of macroautophagy
- peptidyl-serine phosphorylation
- regulation of cardiac muscle contraction
- cellular response to cold
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- cAMP-dependent protein kinase complex
- axoneme
- plasma membrane
- nucleoplasm
- nucleus
- centrosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- calcium channel complex
- cytoplasm
- mitochondrial matrix
- acrosomal vesicle
- dendritic spine
- cytosol
- neuromuscular junction
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- cAMP-dependent protein kinase activity
- protein kinase activity
- protein serine/threonine kinase activity
- magnesium ion binding
- ATP binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- AMP-activated protein kinase activity
- ubiquitin protein ligase binding
- protein kinase A regulatory subunit binding
- manganese ion binding