Adsl Gene Summary [Rat]
Enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; and identical protein binding activity. Involved in several processes, including AMP biosynthetic process; response to hypoxia; and response to muscle activity. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Biomarker of breast cancer. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adsl |
| Official Name | adenylosuccinate lyase [Source:RGD Symbol;Acc:1307617] |
| Ensembl ID | ENSRNOG00000018655 |
| Bio databases IDs | |
| Aliases | adenylosuccinate lyase |
| Synonyms | adenylosuccinate lyase, Adl, AMPS, ASASE, ASL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adsl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidine lyase
- adenylosuccinate lyase
- Lyase class I-like
- lyase
- enzyme
- Adenylosuccinate lyase C-terminus
- identical protein binding
- 3-carboxy-cis,cis-muconate cycloisomerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colon cancer
- adenylosuccinate lyase deficiency
- hereditary disorder
- motor dysfunction
- mucoepidermoid carcinoma
- acinar-cell carcinoma
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
regulates
- AMP
- RPA
- GMP
role in cell
- proliferation
- number
- accumulation in
- dacarbazine sensitivity
- accumulation
- response
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adsl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- AMP salvage
- response to muscle activity
- 'de novo' AMP biosynthetic process
- purine nucleotide biosynthetic process
- response to starvation
- AMP biosynthetic process
- 'de novo' IMP biosynthetic process
- response to nutrient
- GMP biosynthetic process
- 'de novo' XMP biosynthetic process
- response to hypoxia
- aerobic respiration
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
- identical protein binding
- (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity